ECUST New Research Progress of Sensing Detection Technology Based on CRISPR Technology and Nucleic Acid Aptamer published on Science Bulletin

    Targeting the goal of “Green Intelligent Manufacturing”, the research team of Professor Zhang Lixin from the State Key Laboratory of Bioreactor Engineering of ECUST and his collaborators have established a simple, rapid, sensitive, high-throughput and low-cost detection platform for small molecular compounds by using CRISPR-Cas12a technology, referred to as CaT-Smelor Cat Sniffing Technology for short, and developed an upgraded second-generation detection platform CaT-Smelor 2.0, which greatly expanded the types of substrate detection, and at the same time, realized the sensing and efficient detection of various analytes such as proteins.The related research paper “A Versatile Biosensing Platform Coupling Crispr–Cas 12a and Aptamers for Detection of Diverse Analytes was published online in Science Bulletin on September 6th, 2020.

    This paper is co-first authored by Zhao Xiangxiang, a Ph.D. student of ECUST, Li Shanshan, from Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Guang Liu, an assistant researcher of ECUST, and Zhong Wang from South Hospital of the Sixth People’s Hospital affiliated to Shanghai Jiaotong University; and is  co-corresponding authored by Wang Weishan, a visiting professor of East China University of Science and Technology, researcher of Institute of Microbiology, Chinese Academy of Sciences, Tan Gaoyi, an associate professor of State Key Laboratory of Bioreactor Engineering, and Professor Zhang Lixin from ECUST.This research is funded by the National Natural Science Foundation of China, the Open Project of the State Key Laboratory of Bioreactor Engineering and the Natural Science Foundation of Shandong Province.